1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

Base Information

Chemical Name:1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine
CAS No.:177587-43-8
Molecular Formula:C₂₃H₃₃NO₂
Molecular Weight:355.521
Hs Code.:

Synonyms:1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

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Chemical Property of 1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

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Technology Process of 1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

There total 6 articles about 1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177587-26-7
N-t-butoxycarbonyl-1-hexyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]ethylamine

: 177587-43-8
1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jm990135j

Reference yield:

: 111-25-1
1-bromo-hexane

: 177587-43-8
1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / 1,2-dimethoxy-ethane / 1 h / 20 °C

1.2: 1,2-dimethoxy-ethane / 3 h / Heating

2.1: NaH / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

2.2: 1,2-dimethoxy-ethane / 2 h / Heating

3.1: H₂ / 5 percent Pd/C / ethanol

4.1: aq. KOH / ethanol

5.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

5.2: 20 h / Heating

6.1: CF₃CO₂H / CH₂Cl₂ / 1.5 h / 20 °C

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dichloromethane; benzene; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Horner-Emmons condensation / 3.1: Hydrogenation / 4.1: Hydrolysis / 5.1: modified Curtius reaction / 5.2: Alkylation / 6.1: Hydrolysis;
DOI:10.1021/jm990135j

Reference yield:

: 40226-04-8
ethyl 2-(diethoxyphosphoryl)octanoate

: 177587-43-8
1-(4-methoxy-3-phenethyloxy-benzyl)-heptylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

1.2: 1,2-dimethoxy-ethane / 2 h / Heating

2.1: H₂ / 5 percent Pd/C / ethanol

3.1: aq. KOH / ethanol

4.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

4.2: 20 h / Heating

5.1: CF₃CO₂H / CH₂Cl₂ / 1.5 h / 20 °C

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dichloromethane; benzene; 1.1: Metallation / 1.2: Horner-Emmons condensation / 2.1: Hydrogenation / 3.1: Hydrolysis / 4.1: modified Curtius reaction / 4.2: Alkylation / 5.1: Hydrolysis;
DOI:10.1021/jm990135j