2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione
CAS No.:1065482-48-5
Molecular Formula:C₂₅H₁₆ClFN₂O₂
Molecular Weight:430.866
Hs Code.:

Synonyms:2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of 2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

There total 4 articles about 2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.11%

: 136918-14-4,85-41-6
phthalimide

: 1065482-47-4
1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethanol

: 1065482-48-5
2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 59412-12-3
2,5-dichloroquinoline

: 1065482-48-5
2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.25 h / -78 - 0 °C

1.2: 0.5 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

3.1: tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; sodium carbonate; diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; water; acetonitrile;

Reference yield:

: 1064137-50-3
2,5-dichloroquinoline-3-carbaldehyde

: 1065482-48-5
2-(1-(5-chloro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

2: tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C

With di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; water; acetonitrile;