(Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

Base Information

• Chemical Name: (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene
• CAS No.: 103628-14-4
• Molecular Formula: C₃₁H₂₂ClF₇O₂
• Molecular Weight: 594.956
• Mol file: 103628-14-4.mol

Synonyms:(Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

Chemical Property of (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

There total 7 articles about (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C13H4ClF7OZn (129942-65-0) + (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129920-99-6) → (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-14-4) + (E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-15-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 1h; Yield given;

DOI:10.1021/jo00312a027

Reference yield:

1--2-phenyl-butan-1-one (103628-22-4) → (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, BrCH₂CH₂Br / 1.) ether, 20 deg C, 1 h, 2.) 20 h, r.t.

2: conc. HCl / 4 h / Heating

With hydrogenchloride; magnesium; ethylene dibromide;

Reference yield:

C13H4ClF7MgO (129942-66-1) + (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129920-99-6) → (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-14-4) + (E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-15-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00312a027

upstream raw materials:

C₁₃H₄ClF₇MgO

(E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

C₁₃H₄ClF₇OZn

perfluorotoluene

Downstream raw materials:

rel-(1R,2R)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

trans 4-hydroxytamoxifen

(R^*,R^*)-(+/-)-1-<4-(2-dimethylaminoethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

rel-(1R,2S)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane