3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

Base Information

Chemical Name:3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate
CAS No.:1237512-80-9
Molecular Formula:C₂₁H₂₀BrNO₅
Molecular Weight:446.298
Hs Code.:

Synonyms:3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

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Chemical Property of 3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

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Technology Process of 3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

There total 7 articles about 3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1237512-79-6
4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

: 1237512-80-9
3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

Guidance literature:: With sodium metabisulfite; sodium bromate; In cyclohexane; water; ethyl acetate; at 20 ℃;
DOI:10.1002/ardp.200900218

Reference yield:

: 85-44-9
phthalic anhydride

: 1237512-80-9
3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / toluene / 130 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3: sodium metabisulfite; sodium bromate / cyclohexane; water; ethyl acetate / 20 °C

With sodium metabisulfite; sodium bromate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; cyclohexane; water; ethyl acetate; toluene; 2: Mitsunobu reaction;
DOI:10.1002/ardp.200900218

Reference yield:

: 211501-36-9
2-(2-hydroxy-1-methylethyl)-1H-isoindole-1,3(2H)-dione

: 1237512-80-9
3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

2: sodium metabisulfite; sodium bromate / cyclohexane; water; ethyl acetate / 20 °C

With sodium metabisulfite; sodium bromate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; cyclohexane; water; ethyl acetate; 1: Mitsunobu reaction;
DOI:10.1002/ardp.200900218