4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

Base Information

Chemical Name:4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate
CAS No.:1237512-79-6
Molecular Formula:C₂₁H₂₁NO₅
Molecular Weight:367.401
Hs Code.:

Synonyms:4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

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Chemical Property of 4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

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Technology Process of 4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

There total 6 articles about 4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1237512-78-5
2-[2-(4-acetyl-2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione

: 1237512-79-6
4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Reflux;
DOI:10.1002/ardp.200900218

Reference yield:

: 211501-36-9
2-(2-hydroxy-1-methylethyl)-1H-isoindole-1,3(2H)-dione

: 880-06-8
4-hydroxy-3,5-dimethylphenyl acetate

: 1237512-79-6
4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ardp.200900218

Reference yield:

: 85-44-9
phthalic anhydride

: 1237512-79-6
4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / toluene / 130 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; toluene; 2: Mitsunobu reaction;
DOI:10.1002/ardp.200900218