methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate
CAS No.:844470-99-1
Molecular Formula:C₂₀H₁₅FN₄O₂
Molecular Weight:362.363
Hs Code.:

Synonyms:methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

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Chemical Property of methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

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Technology Process of methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

There total 2 articles about methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 844470-97-9
3-bromomethyl-2-(3-fluoro-phenyl)-quinoline-4-carboxylic acid methyl ester

: 288-36-8,288-35-7
1 ,2,3-Triazole

: 844470-99-1
methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

: 844470-98-0
methyl 2-(3-fluorophenyl)-3-(2H-1,2,3-triazol-2-ylmethyl)-4-quinolinecarboxylate

Guidance literature:: 1 ,2,3-Triazole; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 10 - 20 ℃; for 3.5h;

3-bromomethyl-2-(3-fluoro-phenyl)-quinoline-4-carboxylic acid methyl ester; In DMF (N,N-dimethyl-formamide); for 2.5h;

Reference yield:

: 288-36-8
1,2,3-triazole

: 844470-97-9
3-bromomethyl-2-(3-fluoro-phenyl)-quinoline-4-carboxylic acid methyl ester

: 844470-99-1
methyl 2-(3-fluorophenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-4-quinolinecarboxylate

: 844470-98-0
methyl 2-(3-fluorophenyl)-3-(2H-1,2,3-triazol-2-ylmethyl)-4-quinolinecarboxylate

Guidance literature:: 1,2,3-triazole; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h;

3-bromomethyl-2-(3-fluoro-phenyl)-quinoline-4-carboxylic acid methyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1021/op900320j