(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

Base Information

Chemical Name:(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
CAS No.:1181081-71-9
Molecular Formula:C₁₄H₁₄FN₃O₂S
Molecular Weight:307.348
Hs Code.:

Synonyms:(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

Suppliers and Price of (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CLP 257
10mg
$ 460.00

TRC
CLP257
500mg
$ 775.00

Tocris
CLP257 ≥98%(HPLC)
50
$ 878.00

Tocris
CLP257 ≥98%(HPLC)
10
$ 210.00

DC Chemicals
CLP257 >98%
100 mg
$ 550.00

DC Chemicals
CLP257 >98%
250 mg
$ 900.00

DC Chemicals
CLP257 >98%
1 g
$ 1800.00

ChemScene
CLP257 99.25%
100mg
$ 1169.00

AK Scientific
(5Z)-2-(Diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-1,3-thiazol-4-one
1mg
$ 133.00

Total 7 raw suppliers

Chemical Property of (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

Chemical Property:

Boiling Point:473.3±55.0 °C(Predicted)
Density:1.50±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

CLP 257 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.

Technology Process of (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

There total 2 articles about (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1181081-70-8
(5Z)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one

: 89990-53-4,124072-89-5,873221-58-0
tetrahydropyridazine dihydrochloride

: 1181081-71-9
(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

Guidance literature:: With triethylamine; In ethanol; Reflux;

Reference yield: 17.0%

: 1181082-05-2
2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 2-oxopyrrolidine-1-carboxylate

: 1181081-71-9
(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

: 1181082-08-5
2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 2,3-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 2-oxopyrrolidine-1-carboxylate; With sodium tetrahydroborate; In methanol; at -10 - -5 ℃;

With water; ammonium chloride;

Reference yield: 95.0%

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 1181081-71-9
(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

: 1181081-73-1
2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl pyrrolidine-1-carboxylate hydrochloride

Guidance literature:: 1-pyrrolidinecarbonyl chloride; (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one; With potassium carbonate; In acetonitrile; at 80 ℃;

With hydrogenchloride; In methanol;