2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride

Base Information

• Chemical Name: 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride
• CAS No.: 1181081-83-3
• Molecular Formula: C₂₀H₂₃FN₄O₃S*ClH
• Molecular Weight: 454.953
• Mol file: 1181081-83-3.mol

Synonyms:2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride

Chemical Property of 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride

There total 1 articles about 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one (1181081-71-9) + piperidine carbamoyl chloride (13939-69-0) → 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride (1181081-83-3)

Guidance literature:

(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one; piperidine carbamoyl chloride; With potassium carbonate; In acetonitrile; Reflux;

With hydrogenchloride; In 1,4-dioxane; methanol;

upstream raw materials:

(5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

piperidine carbamoyl chloride

Refernces