4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine

Base Information

• Chemical Name: 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine
• CAS No.: 1260402-68-3
• Molecular Formula: C₂₄H₃₂FNOSi
• Molecular Weight: 397.608
• Mol file: 1260402-68-3.mol

Synonyms:4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine

Chemical Property of 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine

There total 5 articles about 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(3-fluorobenzyloxy)-4-nitrobenzene (320337-13-1) + tris-iso-propylsilyl acetylene (89343-06-6) → (2-(2-(3-fluorobenzyloxy)-5-nitrophenyl)ethynyl)triisopropylsilane (1260402-67-2) + 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine (1260402-68-3)

Guidance literature:

With pyrrolidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

(2-(2-(3-fluorobenzyloxy)-5-nitrophenyl)ethynyl)triisopropylsilane (1260402-67-2) → 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine (1260402-68-3)

Guidance literature:

With iron; acetic acid; In ethanol; for 3h; Reflux;

Reference yield:

3-fluoro-benzenemethanol (456-47-3) → 4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine (1260402-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 4 h / Reflux

2: pyrrolidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C

3: acetic acid; iron / ethanol / 3 h / Reflux

With pyrrolidine; copper(l) iodide; iron; potassium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; N,N-dimethyl-formamide; acetone;

upstream raw materials:

3-fluoro-benzenemethanol

2-bromo-1-fluoro-4-nitrobenzene

2-bromo-1-(3-fluorobenzyloxy)-4-nitrobenzene

tris-iso-propylsilyl acetylene

Downstream raw materials:

N-(4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)phenyl)-6-iodoquinazolin-4-amine

5-(4-(4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

N-(4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)phenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine