(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide
CAS No.:1315331-35-1
Molecular Formula:C₂₀H₂₇NO₂S
Molecular Weight:345.506
Hs Code.:

Synonyms:(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

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Technology Process of (S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

There total 6 articles about (S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1315331-14-6
C₂₀H₂₅NO₂S

: 1315331-35-1
(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 - -40 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/ejoc.201100352

Reference yield:

: 874291-47-1
(S)-2-methyl-N-(1-phenylpropylidene)propane-2-sulfinamide

: 100-52-7
benzaldehyde

: 1315331-35-1
(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

: (S)-N-(3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: (S)-2-methyl-N-(1-phenylpropylidene)propane-2-sulfinamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 1h; Schlenk technique; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; at -78 - -20 ℃; Schlenk technique; Inert atmosphere;

With potassium hydroxide; In methanol; at 20 ℃; for 3h; Overall yield = 87%; Overall yield = 0.301 g; diastereoselective reaction;
DOI:10.1021/acs.orglett.5b02919

Reference yield:

: 1315331-14-6
C₂₀H₂₅NO₂S

: 1315331-34-0
C₂₀H₂₇NO₂S

: 1315331-35-1
(S)-N-((1R,2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropyl)-2-methylpropane-2-sulfinamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/ejoc.201100352