2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

Base Information

Chemical Name:2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol
CAS No.:459174-50-6
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

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Technology Process of 2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

There total 3 articles about 2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 64-19-7,77671-22-8
acetic acid

: 444814-26-0
N-[(R)-α-methylbenzyl]aziridine-2(S)-diphenylmethanol

: 459174-50-6
2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: phenylmagnesium bromide

: 459174-50-6
2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 2 h / -78 °C

2: 91 percent / CH₂Cl₂ / 4 h / 20 °C

In tetrahydrofuran; dichloromethane; 1: Grignard reaction;

Reference yield:

: 397849-98-8,397849-97-7
N-[(R)-(+)-α-methylbenzyl]-2(S)-carboxylic acid (-)-menthol ester

: 459174-50-6
2(S)-{N-[(R)-α-methylbenzyl]amino}-3-O-acetyl-1,1-diphenyl-1,3-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 2 h / -78 °C

2: 91 percent / CH₂Cl₂ / 4 h / 20 °C

In tetrahydrofuran; dichloromethane; 1: Grignard reaction;