(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Base Information

Chemical Name:(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
CAS No.:1616101-01-9
Molecular Formula:C₂₀H₁₉F₂N₅OS
Molecular Weight:415.467
Hs Code.:

Synonyms:(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Chemical Property of (4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Technology Process of (4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

There total 14 articles about (4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.41%

: 1616100-74-3
N-(((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-hydroxybutan-2-yl)carbamothioyl)benzamide

: 1616100-25-4
(4S,6S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

: 1616101-01-9
(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 90 ℃;

Reference yield:

: 940879-48-1
1-(2,5-dimethyloxazol-4-yl)ethanol

: 1616100-25-4
(4S,6S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

: 1616101-01-9
(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / chloroform / 12 h / 75 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

3.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.67 h / -78 - -20 °C

4.1: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 20 °C

5.1: dichloromethane / 0.5 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 90 °C

With hydrogenchloride; manganese(IV) oxide; potassium hexamethylsilazane; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; chloroform;

Reference yield:

: 92901-88-7
2,5-Dimethyl-4-oxazolecarboxaldehyde

: 1616100-25-4
(4S,6S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

: 1616101-01-9
(4S,6R)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-6-(2,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether / 1 h / 20 °C

2.1: manganese(IV) oxide / chloroform / 12 h / 75 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 2 h / -78 °C

4.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.67 h / -78 - -20 °C

5.1: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 20 °C

6.1: dichloromethane / 0.5 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 90 °C

With hydrogenchloride; manganese(IV) oxide; potassium hexamethylsilazane; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; chloroform;