MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

Base Information

Chemical Name:MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe
CAS No.:303764-57-0
Molecular Formula:C₅₂H₆₄N₄O₁₁
Molecular Weight:921.1
Hs Code.:

MeO-Leu-Phe-Idac(Bn<sub>2</sub>)-Phe-Leu-OMe

Synonyms:MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

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Chemical Property of MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

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Technology Process of MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

There total 8 articles about MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110462-55-0
1,3:4,6-di-O-benzylidene-2,5-anhydro-D-iditol

: 303764-57-0
MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / Pd/C / methanol; ethyl acetate

2: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C

3: 70 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 0.25 h / 0 °C

4: 95 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

5: 80 percent / NaH / tetrahydrofuran / 1 h / 20 °C

6: PDC; 4 Angstroem molecular sieves / dimethylformamide / 12 h / 20 °C

7: 74 percent / HOBt; EDCI; DIPEA / CH₂Cl₂; dimethylformamide / 6 h / 20 °C

With 1H-imidazole; dipyridinium dichromate; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Condensation / 3: Etherification / 4: Substitution / 5: Tosylation / 6: Oxidation / 7: Condensation;
DOI:10.1021/jo000408e

Reference yield:

: Toluene-4-sulfonic acid (4S,5R,4'R)-5'-hydroxy-2,2'-diphenyl-[4,4']bi[[1,3]dioxanyl]-5-yl ester

: 303764-57-0
MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

Guidance literature:: Multi-step reaction with 8 steps

1: 5 g / K₂CO₃ / methanol / 12 h / 20 °C

2: 100 percent / H₂ / Pd/C / methanol; ethyl acetate

3: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C

4: 70 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 0.25 h / 0 °C

5: 95 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

6: 80 percent / NaH / tetrahydrofuran / 1 h / 20 °C

7: PDC; 4 Angstroem molecular sieves / dimethylformamide / 12 h / 20 °C

8: 74 percent / HOBt; EDCI; DIPEA / CH₂Cl₂; dimethylformamide / 6 h / 20 °C

With 1H-imidazole; dipyridinium dichromate; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: cyclocondensation / 2: Hydrogenolysis / 3: Condensation / 4: Etherification / 5: Substitution / 6: Tosylation / 7: Oxidation / 8: Condensation;
DOI:10.1021/jo000408e

Reference yield:

: 100-39-0
benzyl bromide

: 303764-57-0
MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 0.25 h / 0 °C

2: 95 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

3: 80 percent / NaH / tetrahydrofuran / 1 h / 20 °C

4: PDC; 4 Angstroem molecular sieves / dimethylformamide / 12 h / 20 °C

5: 74 percent / HOBt; EDCI; DIPEA / CH₂Cl₂; dimethylformamide / 6 h / 20 °C

With dipyridinium dichromate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Etherification / 2: Substitution / 3: Tosylation / 4: Oxidation / 5: Condensation;
DOI:10.1021/jo000408e