2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

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Chemical Name:2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid
CAS No.:1191126-52-9
Molecular Formula:C₂₂H₂₆NO₆P
Molecular Weight:431.425
Hs Code.:

Synonyms:2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

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Chemical Property of 2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

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Technology Process of 2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

There total 2 articles about 2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 999-55-3
allyl acrylate

: 118636-74-1
((R)-1-(((benzyloxy)carbonyl)amino)-2-phenylethyl)phosphinic acid

: 1191126-52-9
2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

Guidance literature:: allyl acrylate; ((R)-1-(((benzyloxy)carbonyl)amino)-2-phenylethyl)phosphinic acid; With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

In dichloromethane;
DOI:10.1021/ol902004p

Reference yield:

: (1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl-[2-(ethoxycarbonyl)pent-4-enyl]phosphinic acid

: 1191126-52-9
2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 0 - 20 ℃;
DOI:10.1021/jm9010803

Reference yield:

: 1191126-52-9
2-{[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl(hydroxyl)phosphinoyl]methyl}pent-4-enoic acid

: 13404-22-3
tert-butyl L-alaninate hydrochloride

: 1198770-42-1
(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl[2-({[(1S)-2-(tert-butyloxy)-1-methyl-2-oxoethyl]amino}carbonyl)-pent-4-enyl]phosphinic acid

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jm9010803