Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

Base Information

Chemical Name:Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester
CAS No.:110134-87-7
Molecular Formula:C₂₃H₃₀O₅Si
Molecular Weight:414.574
Hs Code.:

Synonyms:Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

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Technology Process of Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

There total 8 articles about Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110134-86-6
(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

: 110134-87-7
Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

Guidance literature:: With ozone; In methanol; at -78 ℃; Me₂S workup;
DOI:10.1016/S0040-4039(00)87804-1

Reference yield:

: (S)-3,5,6-Trihydroxy-2-methyl-hexanoic acid isopropyl ester

: 110134-87-7
Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide

2: CSA / benzene

3: DIBAH / toluene / -78 °C

4: CSA / methanol; CH₂Cl₂

5: 1) PCC, 2) NaOMe / 1) CH₂Cl₂, 3A-MS, 2) THF

6: 94 percent / NaBH₄, CeCl_3.7H₂O / methanol

7: 98 percent / O₃ / methanol / -78 °C / Me₂S workup

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; sodium methylate; diisobutylaluminium hydride; ozone; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)87804-1

Reference yield:

: 110134-79-7
4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-butyric acid isopropyl ester

: 110134-87-7
Formic acid (1S,3S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: HCl, H₂O / methanol

2: imidazole / dimethylformamide

3: CSA / benzene

4: DIBAH / toluene / -78 °C

5: CSA / methanol; CH₂Cl₂

6: 1) PCC, 2) NaOMe / 1) CH₂Cl₂, 3A-MS, 2) THF

7: 94 percent / NaBH₄, CeCl_3.7H₂O / methanol

8: 98 percent / O₃ / methanol / -78 °C / Me₂S workup

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; water; sodium methylate; diisobutylaluminium hydride; ozone; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)87804-1