(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

Base Information

Chemical Name:(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol
CAS No.:110134-86-6
Molecular Formula:C₂₃H₃₀O₃Si
Molecular Weight:382.575
Hs Code.:

Synonyms:(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

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Chemical Property of (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

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Technology Process of (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

There total 7 articles about (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 110134-85-5
(S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-2,3-dihydro-pyran-4-one

: 110134-86-6
(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol;
DOI:10.1016/S0040-4039(00)87804-1

Reference yield:

: (S)-3,5,6-Trihydroxy-2-methyl-hexanoic acid isopropyl ester

: 110134-86-6
(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide

2: CSA / benzene

3: DIBAH / toluene / -78 °C

4: CSA / methanol; CH₂Cl₂

5: 1) PCC, 2) NaOMe / 1) CH₂Cl₂, 3A-MS, 2) THF

6: 94 percent / NaBH₄, CeCl_3.7H₂O / methanol

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; sodium methylate; diisobutylaluminium hydride; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)87804-1

Reference yield:

: 110134-79-7
4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-butyric acid isopropyl ester

: 110134-86-6
(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-3,4-dihydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: HCl, H₂O / methanol

2: imidazole / dimethylformamide

3: CSA / benzene

4: DIBAH / toluene / -78 °C

5: CSA / methanol; CH₂Cl₂

6: 1) PCC, 2) NaOMe / 1) CH₂Cl₂, 3A-MS, 2) THF

7: 94 percent / NaBH₄, CeCl_3.7H₂O / methanol

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; water; sodium methylate; diisobutylaluminium hydride; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)87804-1