Technology Process of diisopropyl (2S,3S)-2,3-dibenzyloxysuccinate
There total 1 articles about diisopropyl (2S,3S)-2,3-dibenzyloxysuccinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Heating;
DOI:10.1039/P19950002849
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 86 percent / LAH / tetrahydrofuran / 20 °C
2: 92 percent / NaH; nBu4NI / tetrahydrofuran
3: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
4: LHMDS / tetrahydrofuran / 1 h / -78 - 20 °C
5: 83 percent / TBAF / tetrahydrofuran / 0 °C
6: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
7: EtNMe2; LiI; TiCl4 / CH2Cl2 / -78 °C
8: 87 percent / sodium 2-ethylhexanoate / tetrahydrofuran
With
lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-ethanamine; tetrabutyl ammonium fluoride; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; lithium iodide; lithium hexamethyldisilazane; sodium 2-ethylhexanoic acid;
In
tetrahydrofuran; dichloromethane;
4: Julia olefination;
DOI:10.1016/S0040-4039(02)00022-9
