methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

Base Information

Chemical Name:methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate
CAS No.:917223-88-2
Molecular Formula:C₂₀H₂₃FN₂O₃
Molecular Weight:358.413
Hs Code.:

Synonyms:methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

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Chemical Property of methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

Chemical Property:

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Technology Process of methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

There total 7 articles about methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 585544-20-3
6-chloro-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide

: 861905-22-8
methyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 917223-88-2
methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; at 20 - 85 ℃; Product distribution / selectivity;

Reference yield:

: 585544-20-3
6-chloro-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide

: {3-fluoro-2-methyl-5-[(methyloxy)carbonyl]phenyl}boronic acid

: 917223-88-2
methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; at 20 - 80 ℃; for 18h; Product distribution / selectivity;

Reference yield:

: 585544-20-3
6-chloro-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide

: 861905-22-8
methyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 917223-88-2
methyl 3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoate

: 917223-81-5
3-(5-{[(2,2-dimethylpropyl)amino]carbonyl}-2-pyridinyl)-5-fluoro-4-methylbenzoic acid

Guidance literature:: 6-chloro-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide; methyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; With water; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In isopropyl alcohol; at 20 - 85 ℃; for 41h;

With hydrogenchloride; In water; Product distribution / selectivity;