N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide
• CAS No.: 1038914-78-1
• Molecular Formula: C₂₇H₃₆N₂O₆Si
• Molecular Weight: 512.678
• Mol file: 1038914-78-1.mol

Synonyms:N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide

Chemical Property of N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide

There total 1 articles about N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide (953425-38-2) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide (1038914-78-1)

Guidance literature:

N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jm8001185

Reference yield: 66.0%

N-(2-oxo-2-(1-((2-trimethylsilyl)ethoxymethyl)-1H-indol-3-yl)ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide (1038914-78-1) → 3-(3,4,5-trimethoxyphenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indol-3-yl)-1,5-dihydro-2H-pyrrole-2-one (1038914-79-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 0.25h; Reflux; Inert atmosphere;

DOI:10.1021/jm8001185

upstream raw materials:

N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

3-(3,4,5-trimethoxyphenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indol-3-yl)-1,5-dihydro-2H-pyrrole-2-one