Thymidine

Base Information Edit

Chemical Name:Thymidine
CAS No.:50-88-4
Deprecated CAS:35902-13-7
Molecular Formula:C10H14N2O5
Molecular Weight:0
Hs Code.:
European Community (EC) Number:200-070-4
UNII:VC2W18DGKR
DSSTox Substance ID:DTXSID5023661
Nikkaji Number:J4.548I
Wikipedia:Thymidine
Wikidata:Q422464
NCI Thesaurus Code:C880
Pharos Ligand ID:ZPLW32L1R1P3
Metabolomics Workbench ID:37175
ChEMBL ID:CHEMBL52609
Mol file:50-88-4.mol

Synonyms:2' Deoxythymidine;2'-Deoxythymidine;Deoxythymidine;Thymidine

Suppliers and Price of Thymidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Thymidine Edit

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.452g/cm³
XLogP3:-1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:242.09027155
Heavy Atom Count:17
Complexity:381

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Chemical Classes:Biological Agents -> Nucleic Acids and Derivatives
Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
Recent ClinicalTrials:Treatment of TK2 Deficiency With Thymidine and Deoxycytidine
Recent EU Clinical Trials:A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of GlaxoSmithKline Biologicals’ dTpa-IPV vaccine (Boostrix Polio) compared with Sanofi Pasteur MSD’s dTpa-IPV vaccine (Repevax), when co-administered with GSK Biologicals’ MMR vaccine (Priorix) in 3 and 4-year-old healthy children.

Technology Process of Thymidine

There total 455 articles about Thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: thymidine 3'(4-nitrophenylphosphate)

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: With sodium acetate buffer; PDMase; at 37 ℃; for 0.166667h; Rate constant;
DOI:10.1246/bcsj.56.549

Reference yield:

5'-d(AGTAT[5-ethynyl-U]GACCTA)-3': 5'-d(AGTAT[5-ethynyl-U]GACCTA)-3'

: 959326-89-7
2'-deoxycytidine

: 961-07-9
2'-Deoxyguanosine

: 61135-33-9
2'-deoxy-5-ethynyluridine

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

Guidance literature:: With tris hydrochloride; alkaline phosphatase; snake venom phosphodiesterase; at 37 ℃; pH=8.3; Enzymatic reaction;
DOI:10.1002/chem.201001572

Reference yield:

: C₂₃H₃₉N₄O₇P

: C₁₉H₂₅N₃O₁₂P^(1-)

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrazole / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: water; iodine / tetrahydrofuran; acetonitrile / 20 °C

3: hydrazinium monoacetate / methanol; dichloromethane / 2.5 h

4: water; sodium chloride / 72 h / 37 °C / pH 7.5 / Sealed tube; HEPES buffer; Enzymatic reaction

With tetrazole; water; iodine; hydrazinium monoacetate; sodium chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.3390/molecules16010552