(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Base Information

Chemical Name:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride
CAS No.:1307310-16-2
Molecular Formula:C₂₉H₃₄N₄OS*ClH
Molecular Weight:523.142
Hs Code.:

Synonyms:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Suppliers and Price of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

There total 17 articles about (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1307310-14-0
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

: 1307310-16-2
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile; With sodium methylate; In methanol; at 20 - 50 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In methanol; at 50 ℃; Inert atmosphere;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-12-8
C₁₂H₁₅NO₃

: 1307310-16-2
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: Lawessons reagent / tetrahydrofuran / 3 h / Inert atmosphere

2.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere

2.2: 16 h / -5 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

With Lawessons reagent; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-02-6
2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone

: 1307310-16-2
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere

1.2: 16 h / -5 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

4.2: 50 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm2001053