Technology Process of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile
There total 16 articles about (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm2001053
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Lawessons reagent / tetrahydrofuran / 3 h / Inert atmosphere
2.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere
2.2: 16 h / -5 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
Lawessons reagent; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001053
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere
1.2: 16 h / -5 - 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001053