(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Base Information

Chemical Name:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile
CAS No.:1307310-14-0
Molecular Formula:C₂₉H₃₁N₃OS
Molecular Weight:469.651
Hs Code.:

Synonyms:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

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Chemical Property of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

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Technology Process of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

There total 16 articles about (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307310-15-1
C₂₄H₂₅NO₂S

: (S)-pyrrolidine-2-carbonitrile trifluoroacetic acid salt

: 1307310-14-0
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-12-8
C₁₂H₁₅NO₃

: 1307310-14-0
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: Lawessons reagent / tetrahydrofuran / 3 h / Inert atmosphere

2.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere

2.2: 16 h / -5 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With Lawessons reagent; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-02-6
2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone

: 1307310-14-0
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)thiazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 2 h / -5 - 20 °C / Inert atmosphere

1.2: 16 h / -5 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001053