6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Base Information

Chemical Name:6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
CAS No.:1189767-09-6
Molecular Formula:C₁₇H₁₈N₄O₂
Molecular Weight:310.356
Hs Code.:

Synonyms:6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

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Chemical Property of 6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

There total 6 articles about 6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1082745-50-3
5-amino-1-(tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid amide

: 101-97-3
Ethyl 2-phenylethanoate

: 1189767-09-6
6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: With sodium hydride; In ethanol; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm3007799

Reference yield:

: 1-(tetrahydro-2H-pyran-4-yl)hydrazine dihydrogen chloride

: 1189767-09-6
6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethanol / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere; Reflux

2.1: dihydrogen peroxide; ammonia / ethanol; water / 48 h / 20 °C / Inert atmosphere

3.1: sodium hydride / ethanol / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With ammonia; dihydrogen peroxide; sodium hydride; triethylamine; In ethanol; water;
DOI:10.1021/jm3007799

Reference yield:

: 1082745-49-0
5-amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carbonitrile

: 1189767-09-6
6-benzyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; ammonia / ethanol; water / 48 h / 20 °C / Inert atmosphere

2: sodium hydride / ethanol / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With ammonia; dihydrogen peroxide; sodium hydride; In ethanol; water;
DOI:10.1021/jm3007799