tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

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Chemical Name:tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate
CAS No.:1461658-69-4
Molecular Formula:C₂₆H₃₃N₉O₃
Molecular Weight:519.607
Hs Code.:

Synonyms:tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

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Chemical Property of tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

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Technology Process of tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

There total 7 articles about tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1356564-11-8
5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 1461658-67-2
tert-butyl 2-((2-acetamido-4-aminophenyl)(methyl)amino)ethylcarbamate

: 1461658-69-4
tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

Guidance literature:: With potassium fluoride; In 1-methyl-pyrrolidin-2-one; at 130 ℃; Inert atmosphere;

Reference yield:

: 1461658-66-1
tert-butyl 2-((2-acetamido-4-nitrophenyl)(methyl)amino)ethylcarbamate

: 1461658-69-4
tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 25 °C

2: potassium fluoride / 1-methyl-pyrrolidin-2-one / 130 °C / Inert atmosphere

With potassium fluoride; palladium 10% on activated carbon; hydrogen; In 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 454-07-9
N-(2-fluoro-5-nitrophenyl)acetamide

: 1461658-69-4
tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 25 °C

3: potassium fluoride / 1-methyl-pyrrolidin-2-one / 130 °C / Inert atmosphere

With potassium fluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;