454-07-9

Basic information

• Product Name: N1-(2-FLUORO-5-NITROPHENYL)ACETAMIDE
• Synonyms: N1-(2-FLUORO-5-NITROPHENYL)ACETAMIDE;N-(2-Fluoro-5-nitrophenyl)acetamide
• CAS NO: 454-07-9
• Molecular Formula: C₈H₇FN₂O₃
• Molecular Weight: 198.15
• Mol File: 454-07-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 180-182°
• Appearance: /
• CAS DataBase Reference: N1-(2-FLUORO-5-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(2-FLUORO-5-NITROPHENYL)ACETAMIDE(454-07-9)
• EPA Substance Registry System: N1-(2-FLUORO-5-NITROPHENYL)ACETAMIDE(454-07-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 454-07-9(Hazardous Substances Data)

Usage

General Description

N1-(2-Fluoro-5-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H7FN2O3. It is a derivative of acetamide, which is a simple organic compound. This particular derivative contains a fluorine atom and a nitro group attached to a phenyl ring, giving it unique chemical properties. The presence of the nitro group indicates that it can potentially act as a nitroaromatic compound, which may have specific applications in medicinal chemistry, material science, or other fields. The specific characteristics and uses of N1-(2-Fluoro-5-nitrophenyl)acetamide would depend on its individual properties and potential reactivity.

Upstream product

• 369-36-8 6-fluoro-3-nitroaniline 
• 75-36-5 acetyl chloride 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 5991-09-3 N-(5-nitro-2-(4-methylpiperazin-1-yl)phenyl)acetamide 
• 1542259-02-8 tert-butyl (2-fluoro-5-morpholinophenyl)carbamate 
• 500206-01-9 2-fluoro-5-(morpholin-4-yl)aniline 
• 1461658-66-1 tert-butyl 2-((2-acetamido-4-nitrophenyl)(methyl)amino)ethylcarbamate 

Relevant articles and documents

3-Acetamido-4-(cyclooctylamino)nitro-benzene

The crystal and molecular structure of the title compound, N-(2-cyclooctylamino-4-nitrophenyl)acetamide, C16H23N3O3, has been determined as part of an investigation into substituted benzene derivatives having no

Development of a scalable synthesis of a vascular endothelial growth factor receptor-2 kinase inhibitor: Efficient construction of a 6-etherified [1,2,4]triazolo[1,5-a]pyridine-2-amine Core

A practical and scalable synthesis of the vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor 1 has been developed. The key features of the process development include facile preparation of the key raw material 3-amino-4- fluorophenol, chemoselective nucleophilic aromatic substitution of 5-chloro-2-nitropyridine with phenol, a safe one-pot synthesis of a substituted urea using an isothiocyanate generated in situ from inexpensive materials, and improvement of the yield of acylation in the end game. The optimized six-step synthesis afforded 1·H2O in 54% overall yield, twice as much as the yield of the original synthesis, without chromatographic purification. In addition, a robust recrystallization procedure to afford the desired crystal form of 1 was also developed.

3 -CYANO- 5 -ARYLAMINO-7 -CYCLOALKYLAMINOPYRROLO [1, 5 -A] PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS

The invention relates to chemical compounds of Formula (I): or a salt thereof. In some embodiments, the invention relates to inhibitors of CK2. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and treatment of CK2-related conditions and diseases, e.g., cancer.