Technology Process of potassium 4-(benzyloxy)2-(2-nitrophenyl)butanoate
There total 3 articles about potassium 4-(benzyloxy)2-(2-nitrophenyl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-(benzyloxy)-2-(2-nitrophenyl)butanoate;
With
potassium hydroxide;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
pH=4 - 5;
Inert atmosphere;
With
potassium tert-butylate;
In
ethanol;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/anie.201209970
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere
2.2: pH 4 - 5 / Inert atmosphere
2.3: 1 h / 20 °C / Inert atmosphere
With
caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201209970
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere
2.2: pH 4 - 5 / Inert atmosphere
2.3: 1 h / 20 °C / Inert atmosphere
With
caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201209970
