6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

Base Information

Chemical Name:6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine
CAS No.:1622143-97-8
Molecular Formula:C₂₁H₂₄N₅O₇P
Molecular Weight:489.425
Hs Code.:

Synonyms:6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

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Chemical Property of 6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

Chemical Property:

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Technology Process of 6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

There total 2 articles about 6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1622143-86-5
6-(4-cyanophenyl)-9-(5-O-diethylphosphate-2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

: 1622143-97-8
6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.07.110

Reference yield:

: 39824-26-5
6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

: 1622143-97-8
6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 0 °C / Inert atmosphere

2: palladium diacetate; CyJohnPhos; caesium carbonate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / water / 1 h / 20 °C

With palladium diacetate; caesium carbonate; trifluoroacetic acid; CyJohnPhos; In 1,4-dioxane; pyridine; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.07.110

Reference yield:

: 1622143-97-8
6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine

: 5204-74-0
triethylammonium acetate

: C₁₇H₁₆N₅O₇P*C₆H₁₅N

Guidance literature:: 6-(4-cyanophenyl)-9-(5-O-diethylphosphate-β-D-ribofuranosyl)-9H-purine; With trimethylsilyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 36h; Inert atmosphere;

triethylammonium acetate; In N,N-dimethyl-formamide; acetonitrile; pH=7; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.07.110