5204-74-0

Usage

Uses

Used in Molecular Biology:
Triethylammonium acetate is used as a buffer solution for enhancing the visualization and quantification of single mRNA molecules in mammalian tissues, such as those from mice and humans. This application is crucial for understanding gene expression patterns and studying various biological processes at the molecular level.
The use of TEAA in molecular biology allows researchers to gain insights into the regulation of gene expression, which can be applied to the development of new therapeutic strategies and the understanding of disease mechanisms.

InChI:InChI=1/C6H15N.C2H4O2/c1-4-7(5-2)6-3;1-2(3)4/h4-6H2,1-3H3;1H3,(H,3,4)

Upstream product

• 6046-93-1 copper(II) acetate monohydrate 
• 64-19-7 acetic acid 
• 121-44-8 triethylamine 

Downstream Products

• 1249-67-8 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate 

Relevant academic research and scientific papers

Study on absorption and spectral properties of H2S in carboxylate protic ionic liquids with low viscosity

The exorbitant price and high viscosity are two major disadvantages for ionic liquids (ILs), which influence their practical applications in gas separation. Here we synthesized ten carboxylate protic ionic liquids (PILs), containing N-ethylmorpholine acetate, N-ethylmorpholine propionate, N-ethylmorpholine butyrate, N-ethylmorpholine methoxylacetate, 4-(2-hydroxyethyl) morpholine acetate, and 4-(2-hydroxyethyl) morpholine methoxyacetate, triethylamine acetate, triethylamine propionate, triethylamine propionate, and triethylamine methoxylacetate, with low cost and viscosity for absorption of H2S. The densities and viscosities of these carboxylate PILs were measured in the temperature range of (298.2 to 333.2) K at atmospheric pressure. The solubility of H2S in these PILs was determined using an isochoric saturation technique at 298.2–318.2 K and 0–1.096 bar. It was found that the solubility of H2S in these PILs increased with the increasing pressure and length of the alkyl chains on the carboxylic acid. The absorption processes obeyed Henry's law within the given experimental conditions and Henry's constants were calculated from solubility data. In addition, the FTIR and NMR spectral properties in the absorption process of H2S in N-ethylmorpholine butyrate [NEMH][Bu] also were investigated to present important information on absorption mechanism. The results indicated that [NEMH][Bu] demonstrated a highest absorption capacity among these PILs and absorption of H2S is a physical behavior. Comparisons of PILs with the common ILs and organic solvents were also done to demonstrate the advantages of PILs.

Synthesis of micro/mesoporous silica material by duallate method as a heterogeneous catalyst support for alkylation

A series of micro/mesoporous composites were synthesized using non-ionic block copolymer Pluronic P123 and protic ionic liquid (triethylamine acetate) as the colates. The structures of all the composites were characterized by using small angle X-ray scattering, N2 gas sorption, dynamic laser light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results reflected that the structure of the final silica materials changes along with the content of protic ionic liquid (PIL) and hydrothermal temperature. It was found that the sample whose mass ratio of PIL to (P123 + PIL) was 40% had a t-plot micropore area of 404 m2 g-1 at the hydrothermal temperature of 373 K, without destroying the ordered mesoporous structure. The formation mechanism of the micro/mesoporous silica which is based on the interaction between PIL and P123 is tentatively elucidated. 12-Tungstophosphoric acid (HPW) catalysts supported on these micro/mesoporous materials were prepared by impregnation, and their catalytic performances were investigated in the alkylation of o-xylene with styrene. Alkylation results showed that all the catalysts showed high catalytic performance in terms of propane conversion and selectivity to propene.

Peptides in aqueous protic ionic liquid solutions: Apparent and transfer volumes at 298.15 K and at 0.1 MPa

The densities of glycine based peptides namely glycyl-glycine (digly), glycine-?-valine (gly-val), glycyl-?-leucine (gly-leu) and glycyl-glycyl-glycine (triglycine/trigly) in aqueous solutions containing ~0.20 mol·kg?1 of triethylammonium acetate [TEAA], triethylammonium glycolate [TEAG], triethylammonium pyruvate [TEAPy] and triethylammonium propionate [TEAP] protic ionic liquids (PILs) are reported at 298.15 K and at atmospheric pressure. Experimental density data obtained for these systems were used to estimate apparent molar volume (?V), the limiting apparent molar volume (?V0), partial molar volume of solute (Vˉ2) and partial molar volume of mixed solvent (PILs + water) (Vˉ1). The change in limiting apparent molar volume due to transfer (Δtr?V0) of peptides from water to aqueous ionic liquid solutions were also estimated. The outcomes obtained from all these thermodynamic parameters were discussed in terms of ion–peptide interactions, ion–ion interactions, hydrophobic solvation, peptide group contributions to limiting volumes, etc.

Infrared spectroscopic study on chemical and phase equilibrium in triethylammonium acetate

Protic ionic liquid (PIL) triethylammonium acetate was prepared by mixing equimolar amounts of acetic acid and triethylamine, and then studied using the combination of the Attenuated Total Reflection Fourier Transform Infrared spectroscopy, in-situ infrared spectroscopy, pH, and conductivity titration measurements. It was found that the equimolar synthesized triethylammonium acetate was separated into two layers, which suggesting that there were both chemical and phase equilibrium in this solution. Molecular species could be directly observed in the IR spectra over the range of 1200-1800 cm?1 and also checked by 1H NMR. Based on analysis, the upper layer was rich in amine with little acid and PIL, and the down layer was rich in PIL with residual acetic acid and amine. And single PIL-rich layer could be separated into two layers again when the mole ratio of newly added triethyamine to the theoretical produced triethylammonium acetate reached 0.12.

Synthesis and potent antimicrobial activity of novel coumarylthiazole α-aminophosphonates derivatives

Abstract: Herein, we reported a novel series of?α-aminophosphonates derivatives (IV)a–m bearing an important pharmacophore coumarylthiazole moiety. All the new compounds have been synthesized?via?Kabachnik–Fields reaction under ultrasonic irradiation. The products were obtained in good yield with a simple workup and were confirmed using various spectroscopic methods. All these compounds (IV)a–m were screened for their in vitro for antimicrobial activity against thirteen Gram-negative bacteria and five Gram-positive bacteria and Candida albicans strains. The results showed that all the synthesized compounds exhibited moderate antibacterial activities against both references and multidrug-resistant and antifungal strains. The compound?(IV)e?showed the highest activities against all pathogens of the tested microbial strains with?MIC of 0.125?μg/mL.?The compounds (IV)h, (IV)f, (IV)b, and (IV)d exhibited moderate and promising activities with MIC of 0.125?μg/mL. Structure–activity relationship revealed that inhibitory activity of the synthesized compounds is related to the type of the substituted group on phenyl rings, and these results showed that the electron-donating groups at?ortho?and?para?positions have a high relationship increasing antimicrobial activities than the electron‐withdrawing groups. These results confirm that coumarylthiazole α-aminophosphonates compounds can be potential antimicrobial drugs candidate. Graphic abstract: [Figure not available: see fulltext.].

Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions

Abstract: The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract: Various aldehydes, malononitrile and activated phenols could be converted to thecorresponding 2-amino-4H-chromenes with good to excellent isolated yields underthe catalysis of choline acetate at room temperature. [Figure not available: see fulltext.]

QUINONE METHIDE AND AMMONIUM SALT ANTIPOLYMERANT COMPOSITION AND METHOD

Described are compositions and methods for inhibiting polymerization of a monomer (e.g., styrene) composition a quinone methide polymerization retarder and an ammonium salt. In a mixture, the ammonium salt improves the efficacy of the quinone methide polymerization retarder and provides greater antipolymerant activity. In turn, the mixture reduces or prevents apparatus fouling and improves the purity of monomer streams.

Simple protic ionic liquid [Et3NH][HSO4] as a proficient catalyst for facile synthesis of biscoumarins

Abstract: We have explored a number of protic ionic liquids (PILs) as a catalyst for the synthesis of biscoumarins by condensation of 4-hydroxycoumarin with an aromatic aldehyde. Methylimidazolium- and triethylammonium-based PILs were synthesized by simple neutralization reaction with protic acids. Triethylammonium hydrogen sulfate [Et3NH][HSO4] was found to be the best among the studied PILs concerning the yield of products and reaction time period. Different biscoumarin derivatives were synthesized based on 4-hydroxycoumarin and various substituted aromatic aldehydes at optimum reaction conditions. Obtained products were separated just by simple filtration. The facile method does not require additional purification for formed products. The catalyst has shown better yields along with outstanding recyclability, providing an environmental benign protocol for the synthesis of biscoumarin derivatives. Graphical Abstract: Screening of simple protic ionic liquids as a catalyst in the synthesis of biscoumarins, out of which [Et3NH][HSO4] was found to be best among the studied PILs.

Preparation method of key midbody allene sulfoxide matter of dexamethasone

The invention discloses a preparation method of key midbody allene sulfoxide matter of dexamethasone. The preparation method includes steps of adding an organic solvent (I) containing weak acid and weak base salt to a compound shown in Formula A; then adding to an organic solvent (II) containing chorine fenbendazole and reacting; after reaction, collecting a compound shown in Formula B from a reaction product. The method has the beneficial effects that the product does not use cyanide and heavy metals, and is good for large-scale industrial production; the yield is over 124%, which is greatly higher than that of the prior art; the production cost is reduced, and the technical innovation of the preparation technique of dexamethasone and other steroids containing C17 side chain is promoted; meanwhile, the method also provides a thinking for the preparation of the steroids with the side chain. The reaction general formula is shown as below: FORMULA.

Efficient and selective N-, S- and O-acetylation in TEAA ionic liquid as green solvent. Applications in synthetic carbohydrate chemistry

Background: The ionic liquid triethylammonium acetate (TEAA) was found to be an efficient solvent in the acetylation of alcohols, amines, oximes and thiols to their corresponding acetyl compounds using only a 10% excess of acetic anhydride under mild conditions. Moreover TEAA is not only an inexpensive and recyclable solvent but also an anomeric selective catalyst in the per-O-acetylation of sugar moieties. Methods: Simple and effective organic synthesis protocols were provided for the selective acetylation of several substrates. The products were fully characterized by 1H and 13C NMR spectroscopy and the anomeric ratios were obtained from the 1H spectra. Results: Structurally diverse alcohols, phenols, thiols, amines, carbohydrates and oximes underwent acylation under mild conditions by this procedure to provide the corresponding acetates in excellent yields. TEAA ionic liquid is unique in its capability to act as both, solvent and high selective catalyst. As expected, the reaction proceeds with high b anomeric selectivity for sugars derivatives. Moreover, the ionic liquid was regenerated, recycled and reused for three times without apparent loss of reactivity and selectivity in all cases. Conclusions: The present procedure provides a powerful and versatile acylation method for alcohols, phenols, thiols, amines, oximes and carbohydrates. This protocol is endowed with several unique merits: selectivity, cost-efficiency, atom-economy and mild reaction conditions tolerable to acid sensitive functionalities. With these features, this method may be considered as a better alternative for the acetylation of a wide range of substrates.