(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Base Information

Chemical Name:(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol
CAS No.:1298044-31-1
Molecular Formula:C₃₀H₂₆BrNO₃
Molecular Weight:528.445
Hs Code.:

Synonyms:(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Suppliers and Price of (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

There total 11 articles about (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1298044-29-7
C₃₀H₂₄BrNO₃

: 1298044-31-1
(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Guidance literature:: C₃₀H₂₄BrNO₃; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;

With water; In methanol;
DOI:10.1002/ejoc.201001720

Reference yield:

: 1298044-27-5
(1R)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(naphthalen-1-yl)-1-phenylpent-4-en-2-ol

: 1298044-31-1
(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 2 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; methanol; water;
DOI:10.1002/ejoc.201001720

Reference yield:

: 1298044-17-3
(E)-3-(6-bromo-2-methoxyquinolin-3-yl)prop-2-en-1-ol

: 1298044-31-1
(4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol

Guidance literature:: Multi-step reaction with 8 steps

1.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.67 h / -20 °C / Molecular sieve

1.2: 4 h / -20 °C

2.1: copper(l) cyanide / tetrahydrofuran; diethyl ether / 1 h / -40 °C

2.2: 3 h / -40 °C

2.3: 3 h

3.1: / dichloromethane / 1 h / 0 - 20 °C

4.1: diethyl ether / 1 h / 0 °C

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

6.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.17 h / 20 °C

6.2: 0.5 h

7.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 2 h / 20 °C

8.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; titanium(IV) isopropylate; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; copper(I) bromide dimethylsulfide complex; L-(+)-diisopropyl tartrate; copper(l) cyanide; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 1.1: Sharpless epoxidation / 1.2: Sharpless epoxidation / 6.2: Barbier type reaction;
DOI:10.1002/ejoc.201001720