Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-

Base Information

Chemical Name:Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-
CAS No.:1298044-25-3
Molecular Formula:C₂₈H₂₀BrNO₂
Molecular Weight:482.376
Hs Code.:
DSSTox Substance ID:DTXSID001143704

Synonyms:1298044-25-3;(R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethan-1-one;2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanone;Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-;DTXSID001143704;CS-M2946;YBC04425;AKOS037650467;CS-14852;(2R)-2-(6-Bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenylethanone

Suppliers and Price of Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
(R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethan-1-one
25mg
$ 750.00

Total 3 raw suppliers

Chemical Property of Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-

Chemical Property:

XLogP3:7.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:481.06774
Heavy Atom Count:32
Complexity:635

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethan-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C=C(C=CC2=N1)Br)C(C3=CC=CC=C3)C(=O)C4=CC=CC5=CC=CC=C54
Isomeric SMILES:COC1=C(C=C2C=C(C=CC2=N1)Br)[C@@H](C3=CC=CC=C3)C(=O)C4=CC=CC5=CC=CC=C54

Technology Process of Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)-

There total 8 articles about Ethanone, 2-(6-bromo-2-methoxy-3-quinolinyl)-1-(1-naphthalenyl)-2-phenyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1298044-24-2
(2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanol

: 1298044-25-3
(2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanone

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/ejoc.201001720

Reference yield:

: 1298044-17-3
(E)-3-(6-bromo-2-methoxyquinolin-3-yl)prop-2-en-1-ol

: 1298044-25-3
(2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.67 h / -20 °C / Molecular sieve

1.2: 4 h / -20 °C

2.1: copper(l) cyanide / tetrahydrofuran; diethyl ether / 1 h / -40 °C

2.2: 3 h / -40 °C

2.3: 3 h

3.1: / dichloromethane / 1 h / 0 - 20 °C

4.1: diethyl ether / 1 h / 0 °C

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

With titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; copper(l) cyanide; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Sharpless epoxidation / 1.2: Sharpless epoxidation;
DOI:10.1002/ejoc.201001720

Reference yield:

: 1298044-13-9
ethyl (E)-3-(6-bromo-2-chloroquinolin-3-yl)acrylate

: 1298044-25-3
(2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / 0 - 20 °C

1.2: 4 h

2.1: methanol / 8 h / 80 °C

3.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.67 h / -20 °C / Molecular sieve

3.2: 4 h / -20 °C

4.1: copper(l) cyanide / tetrahydrofuran; diethyl ether / 1 h / -40 °C

4.2: 3 h / -40 °C

4.3: 3 h

5.1: / dichloromethane / 1 h / 0 - 20 °C

6.1: diethyl ether / 1 h / 0 °C

7.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

With titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; copper(l) cyanide; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 3.1: Sharpless epoxidation / 3.2: Sharpless epoxidation;
DOI:10.1002/ejoc.201001720