(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

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Chemical Name:(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone
CAS No.:129103-96-4
Molecular Formula:C₁₉H₁₇FO₆
Molecular Weight:360.339
Hs Code.:

Synonyms:(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

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Chemical Property of (2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

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Technology Process of (2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

There total 4 articles about (2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 129103-85-1
2-Fluoro-6-methoxy-benzoic acid (3aS,8aR)-5-iodo-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-4-yl ester

: 129103-96-4
(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -70 ℃; for 2h;
DOI:10.1021/jo00302a011

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 129103-96-4
(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / KOH / H₂O / 3 h / Heating

2: (COCl)2, DMF / tetrahydrofuran

3: pyridine

4: 63 percent / n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 2 h / -70 °C

With pyridine; potassium hydroxide; n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1021/jo00302a011

Reference yield:

: 500912-12-9
2-fluoro-6-methoxybenzoyl chloride

: 129103-96-4
(2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 63 percent / n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 2 h / -70 °C

With pyridine; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo00302a011