2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

Base Information

Chemical Name:2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid
CAS No.:1374760-74-3
Molecular Formula:C₂₄H₁₅N₃O₇S
Molecular Weight:489.465
Hs Code.:

Synonyms:2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

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Chemical Property of 2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

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Technology Process of 2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

There total 4 articles about 2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1374760-85-6
ethyl 2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetate

: 1374760-74-3
2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

Guidance literature:: ethyl 2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetate; With sodium hydroxide; In tetrahydrofuran; water; acetone; at 20 ℃; for 1h;

With hydrogenchloride; In water; for 0.5h; pH=2; Cooling with ice;
DOI:10.1016/j.bmc.2012.03.005

Reference yield:

: 1374760-68-5
ethyl 2-(4-amino-2-benzoylphenylamino)-2-oxoacetate

: 1374760-74-3
2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 0.5 h / 110 °C

2.1: sodium hydroxide / tetrahydrofuran; water; acetone / 1 h / 20 °C

2.2: 0.5 h / pH 2 / Cooling with ice

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmc.2012.03.005

Reference yield:

: 401640-32-2
ethyl 2-(2-benzoyl-4-nitrophenylamino)-2-oxoacetate

: 1374760-74-3
2-(2-benzoyl-4-(6-nitrobenzo[b]thiophene-2-carboxamido)phenylamino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / trifluoroethanol / 3 h / 20 °C / 760.05 Torr

2.1: N-ethyl-N,N-diisopropylamine / toluene / 0.5 h / 110 °C

3.1: sodium hydroxide / tetrahydrofuran; water; acetone / 1 h / 20 °C

3.2: 0.5 h / pH 2 / Cooling with ice

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; trifluoroethanol; water; acetone; toluene;
DOI:10.1016/j.bmc.2012.03.005