(R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Base Information

• Chemical Name: (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol
• CAS No.: 1311269-29-0
• Molecular Formula: C₁₆H₁₇BrN₂O
• Molecular Weight: 333.228

Synonyms:(R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Chemical Property of (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

There total 3 articles about (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione (1311269-26-7) → (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol (1311269-29-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 18h; Reflux; Inert atmosphere;

DOI:10.1002/anie.201101210

Reference yield:

D-tyrosine methylester hydrochloride (3728-20-9) → (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol (1311269-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / 96 h / Reflux; Inert atmosphere

2: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

With pyridine; dmap; borane-THF; In tetrahydrofuran;

DOI:10.1002/anie.201101210

Reference yield:

5-bromoisatoic anhydride (4692-98-2) → (R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol (1311269-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / 96 h / Reflux; Inert atmosphere

2: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

With pyridine; dmap; borane-THF; In tetrahydrofuran;

DOI:10.1002/anie.201101210

upstream raw materials:

(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

5-bromoisatoic anhydride

D-tyrosine methylester hydrochloride

Downstream raw materials:

(3R)-3-[(4-butoxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

(R)-4-((7-(3-chlorophenyl)-4-(4-methoxyphenylsulfonyl)-1-((1-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

5-[(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

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