(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

Base Information

Chemical Name:(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile
CAS No.:1311269-17-6
Molecular Formula:C₃₄H₃₇N₅O₄S
Molecular Weight:611.765
Hs Code.:

(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

Synonyms:(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

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Chemical Property of (3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

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Technology Process of (3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

There total 8 articles about (3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1311269-32-5
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 870-63-3
prenyl bromide

: 1311269-17-6
(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-29-0
(R)-4-((7-bromo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)methyl)phenol

: 1311269-17-6
(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 0.5 h / 200 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2.1: pyridine / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

3.2: 20 °C / Iknert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-28-9
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 1311269-17-6
(3R)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

1.2: 20 °C / Iknert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201101210