benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate
• CAS No.: 1210538-80-9
• Molecular Formula: C₂₁H₂₄N₂O₅S
• Molecular Weight: 416.498
• Mol file: 1210538-80-9.mol

Synonyms:benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate

Chemical Property of benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate

There total 1 articles about benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H20N2O3 + benzenesulfonyl chloride (98-09-9) → benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate (1210538-80-9)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.08.094

Reference yield:

benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate (1210538-80-9) → 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane (1170830-83-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 2h;

DOI:10.1016/j.bmcl.2011.08.094

Reference yield:

benzyl 4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate (1210538-80-9) → N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide (1208657-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h

2: triethylamine / tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2011.08.094

upstream raw materials:

benzenesulfonyl chloride

Downstream raw materials:

4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane

N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide