N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

Base Information

Chemical Name:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine
CAS No.:86778-74-7
Molecular Formula:C₂₇H₃₄N₂O₇
Molecular Weight:498.576
Hs Code.:

Synonyms:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

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Technology Process of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

There total 6 articles about N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 86778-73-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

: 86778-74-7
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

Guidance literature:: With sodium hydroxide; In methanol; at 25 ℃;
DOI:10.1021/jm00369a017

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 86778-74-7
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

2: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

3: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

4: 66 percent / 2.5 N NaOH / methanol / 25 °C

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 86778-74-7
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1: 48percent HBr / acetic acid / Heating

2: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

3: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

4: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

5: 66 percent / 2.5 N NaOH / methanol / 25 °C

With N-Ethylmaleimide; sodium hydroxide; hydrogen bromide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017