N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine

Base Information

• Chemical Name: N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine
• CAS No.: 1026032-15-4
• Molecular Formula: C₃₉H₄₃N₄O₇P
• Molecular Weight: 710.767

Synonyms:N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine

Chemical Property of N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine

There total 4 articles about N⁴-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N4-benzoyl-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-6-azacytosine (933460-56-1) + diisopropyl [((p-tolylsulfonyl)oxy)methyl]phosphonate → N4-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine (1026032-15-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at -20 - 20 ℃;

DOI:10.1021/jm061281+

Reference yield:

1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-6-azacytosine (933460-55-0) → N4-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine (1026032-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / dimethylformamide / 96 h / 20 °C

2: 73 percent / sodium hydride / dimethylformamide / -20 - 20 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm061281+

Reference yield:

benzoic acid anhydride (93-97-0) → N4-benzoyl-1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-6-azacytosine (1026032-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / dimethylformamide / 96 h / 20 °C

2: 73 percent / sodium hydride / dimethylformamide / -20 - 20 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm061281+

upstream raw materials:

N⁴-benzoyl-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-6-azacytosine

1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-6-azacytosine

benzoic acid anhydride

(S)-tritylglycidol

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