4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Base Information

Chemical Name:4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt
CAS No.:1392150-79-6
Molecular Formula:C₂HF₃O₂*C₂₀H₂₅F₃N₂O₄
Molecular Weight:528.449
Hs Code.:

Synonyms:4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

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Chemical Property of 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

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Technology Process of 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

There total 8 articles about 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1392150-84-3
tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

: 76-05-1
trifluoroacetic acid

: 1392150-79-6
4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;

Reference yield: 53.0%

: tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate trifluoroacetate

: 1392150-79-6
4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1392150-80-9
tert-butyl 2-nitro-4-(pyridin-4-yl)benzoate

: 1392150-79-6
4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahvdro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 20 - 60 °C

2: hydrogen / platinum(IV) oxide / methanol / 24 h / 3750.38 Torr

3: trifluoroacetic acid; tetramethylammonium triacetoxyborohydride / dichloromethane / 2 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

5: dichloromethane / 16 h / 20 °C

With hydrogen; triethylamine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride; platinum(IV) oxide; In methanol; dichloromethane; acetone;