tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

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Chemical Name:tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate
CAS No.:1392150-84-3
Molecular Formula:C₂₄H₃₃F₃N₂O₄
Molecular Weight:470.532
Hs Code.:

Synonyms:tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

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Chemical Property of tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

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Technology Process of tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

There total 5 articles about tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1392150-83-2
tert-butyl 4-(1-methylpiperidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzoate

: 407-25-0
trifluoroacetic anhydride

: 1392150-84-3
tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1392150-84-3
tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 24 h / 100 °C

2: acetone / 20 - 60 °C

3: hydrogen / platinum(IV) oxide / methanol / 24 h / 3750.38 Torr

4: trifluoroacetic acid; tetramethylammonium triacetoxyborohydride / dichloromethane / 2 h / 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen; sodium carbonate; triethylamine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; dichloromethane; water; acetone;

Reference yield:

: 1392150-81-0
4-(4-(tert-butoxycarbonyl)-3-nitrophenyl)-1-methylpyridin-1-ium iodide

: 1392150-84-3
tert-butyl 4-(1-methylpiperidin-4-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / platinum(IV) oxide / methanol / 24 h / 3750.38 Torr

2: trifluoroacetic acid; tetramethylammonium triacetoxyborohydride / dichloromethane / 2 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen; triethylamine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride; platinum(IV) oxide; In methanol; dichloromethane;