(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Base Information

Chemical Name:(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine
CAS No.:1404085-28-4
Molecular Formula:C₁₅H₁₄F₂N₄O
Molecular Weight:304.299
Hs Code.:

Synonyms:(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

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Technology Process of (S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

There total 3 articles about (S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1404085-27-3
(S)-tert-butyl 1-((3-amino-6-methoxypyridin-2-yl)(3,5-difluorophenyl)amino)-1-oxopropan-2-ylcarbamate

: 1404085-28-4
(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Guidance literature:: (S)-tert-butyl 1-((3-amino-6-methoxypyridin-2-yl)(3,5-difluorophenyl)amino)-1-oxopropan-2-ylcarbamate; With acetic acid; at 130 ℃;

With hydrogenchloride; In methanol; water; at 80 ℃;

Reference yield: 60.0%

: 1404085-28-4
(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Guidance literature:

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 1404085-28-4
(S)-1-(3-(3,5-difluorophenyl)-5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 760.05 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

4.1: acetic acid / 130 °C

4.2: 80 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;