5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Base Information

Chemical Name:5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid
CAS No.:1234015-55-4
Molecular Formula:CH₄O₃S*C₁₈H₁₉N₇O₂
Molecular Weight:461.502
Hs Code.:

Synonyms:5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Suppliers and Price of 5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PrexasertibMesylate
5mg
$ 145.00

Total 2 raw suppliers

Chemical Property of 5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

PrexasertibMesylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Prexasertib Mesylate is a novel CHK1 inhibitor under investigation as a chemopotentiating agent. It causes double-stranded DNA breakage while simultaneously removing the protection of the DNA damage checkpoints. Prexasertib Mesylate is representative of a novel class of drugs for the treatment of cancer and tumor growth inhibition.

Technology Process of 5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

There total 12 articles about 5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile dimesylate

: 1234015-55-4
5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Guidance literature:: With sodium hydroxide; In water; at 20 - 60 ℃; Industry scale;

Reference yield: 74.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1234015-52-1
5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile

: 1234015-55-4
5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Guidance literature:: In methanol; Sonographic reaction;

Reference yield:

: 1234015-62-3
1-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-3,3-bis(methylsulfonyl)-2-propen-1-one

: 1234015-55-4
5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -78 - 20 °C

1.2: 10.25 h / 0 °C / Reflux

1.3: 8 h / Reflux

2.1: hydrogenchloride / methanol / 2.33 h

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

5.1: acetone / 52 °C / Industry scale

6.1: sodium hydroxide / water / 1 h / 60 °C / Industry scale

With hydrogenchloride; n-butyllithium; di-isopropyl azodicarboxylate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetone;