6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

Base Information

Chemical Name:6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine
CAS No.:1643718-93-7
Molecular Formula:C₁₇H₂₅NO₂
Molecular Weight:275.391
Hs Code.:

Synonyms:6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

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Chemical Property of 6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

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Technology Process of 6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

There total 6 articles about 6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1643718-92-6
tert-butyl-N-6-[4-(pent-4-ynyloxy)phenyloxy]hexylcarbamate

: 1643718-93-7
6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 21h;
DOI:10.1002/ejoc.201402249

Reference yield:

: 103-16-2
4-Benzyloxyphenol

: 1643718-93-7
6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 21 h / Inert atmosphere; Reflux

2.1: N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

3.1: hydrazine hydrate / dichloromethane; methanol / 17 h / 20 °C

4.1: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

5.1: hydrogen; palladium 10% on activated carbon / chloroform; ethyl acetate / 23 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

6.2: 22 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 21 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; 3.1: |Gabriel Amine Synthesis;
DOI:10.1002/ejoc.201402249

Reference yield:

: 1643718-88-0
N-[6-(4-benzyloxyphenyloxy)hexyl]phthalimide

: 1643718-93-7
6-[4-(pent-4-ynyloxy)phenyloxy]hexylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / dichloromethane; methanol / 17 h / 20 °C

2.1: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / chloroform; ethyl acetate / 23 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

4.2: 22 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 21 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Gabriel Amine Synthesis;
DOI:10.1002/ejoc.201402249