(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

Base Information

Chemical Name:(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline
CAS No.:208935-32-4
Molecular Formula:C₁₈H₂₇NO₂Si
Molecular Weight:317.503
Hs Code.:

Synonyms:(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

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Chemical Property of (4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

Chemical Property:

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Technology Process of (4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

There total 6 articles about (4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 482315-16-2
C₂₀H₃₁NO₄Si

: 208935-32-4
(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; for 24h; Heating;
DOI:10.1021/ol020164f

Reference yield:

: 503560-10-9
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-benzamide

: 208935-32-4
(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 °C

2: 95 percent / CH₂Cl₂; pyridine

3: 87 percent / K₂CO₃ / Pd(PPh₃)4 / acetonitrile / 60 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; dichloromethane; acetonitrile; 2: acetylation;
DOI:10.1016/S0040-4039(02)02371-7

Reference yield:

: N-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethyl]-benzamide

: 208935-32-4
(4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodinane / CH₂Cl₂

2: tetrahydrofuran / 0 °C

3: 95 percent / CH₂Cl₂; pyridine

4: 87 percent / K₂CO₃ / Pd(PPh₃)4 / acetonitrile / 60 °C

With potassium carbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; dichloromethane; acetonitrile; 3: acetylation;
DOI:10.1016/S0040-4039(02)02371-7