tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

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Chemical Name:tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate
CAS No.:234081-52-8
Molecular Formula:C₂₄H₃₃FN₆O₃
Molecular Weight:472.563
Hs Code.:

Synonyms:tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

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Chemical Property of tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

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Technology Process of tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

There total 6 articles about tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 234081-47-1
tert-butyl (2S)-benzyloxycarbonylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

: 64-17-5
ethanol

: 234081-52-8
tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 234082-10-1
methyl 3-fluoro-4-(piperazin-1-yl)benzoate

: 234081-52-8
tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / N,N-diisopropylethylamine / dimethylformamide / 4.5 h / 120 °C

2: 85 percent / NaOH / methanol; tetrahydrofuran; H₂O / 5 h / 40 °C

3: 76 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

4: 33 percent / H₂ / Pd/C / tetrahydrofuran / 24 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 234082-11-2
methyl 3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoate

: 234081-52-8
tert-butyl (2S)-ethylamino-3-[3-fluoro-4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaOH / methanol; tetrahydrofuran; H₂O / 5 h / 40 °C

2: 76 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

3: 33 percent / H₂ / Pd/C / tetrahydrofuran / 24 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060