(4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

Base Information

Chemical Name:(4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride
CAS No.:1365776-33-5
Molecular Formula:C₁₆H₂₂ClFN₂*ClH
Molecular Weight:333.276
Hs Code.:

Synonyms:(4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

Suppliers and Price of (4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

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Chemical Property of (4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

Chemical Property:

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Technology Process of (4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

There total 2 articles about (4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 60811-21-4
1-bromo-3-chloro-4-fluorobenzene

: 1365793-92-5
(4aR,8aS)-2,2-dimethyldecahydroquinoxaline

: 1365776-33-5
(4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

Guidance literature:: 1-bromo-3-chloro-4-fluorobenzene; (4aR,8aS)-2,2-dimethyldecahydroquinoxaline; With sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In toluene; for 5h; Reflux; Inert atmosphere;

With hydrogenchloride; In ethanol;

Reference yield:

: cis-2,2-dimethyldecahydroquinoxaline

: 1365776-33-5
(4aS,8aR)-1-(3-chloro-4-fluorophenyl)-3,3-dimethyldecahydroquinoxaline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: O,O'-dibenzoyl-L-tartaric acid / ethanol / 0.5 h / 20 °C / Reflux

1.2: 20 °C

2.1: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; sodium t-butanolate / toluene / 5 h / Reflux; Inert atmosphere

With palladium diacetate; O,O'-dibenzoyl-L-tartaric acid; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In ethanol; toluene;