[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

Base Information

Chemical Name:[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol
CAS No.:1280732-93-5
Molecular Formula:C₂₁H₁₆BrF₃N₄O₂
Molecular Weight:493.283
Hs Code.:

Synonyms:[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

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Chemical Property of [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

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Technology Process of [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

There total 5 articles about [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280732-59-3
1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-prop-2-yn-1-ol

: 402-23-3
1-bromomethyl-3-trifluoromethylbenzene

: 1280732-93-5
[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

Guidance literature:: 1-bromomethyl-3-trifluoromethylbenzene; With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 2h;

1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-prop-2-yn-1-ol; With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dimethyl sulfoxide; at 20 ℃; for 48h;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280732-93-5
[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2.1: lithium borohydride; ethanol / 60 °C

3.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

4.1: tetrahydrofuran / 1 h / -78 - 20 °C

5.1: sodium azide / dimethyl sulfoxide / 2 h / 20 °C

5.2: 48 h / 20 °C

With lithium borohydride; sodium azide; ethanol; hydroxylamine hydrochloride; acetic acid; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1280732-93-5
[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride; ethanol / 60 °C

2.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

3.1: tetrahydrofuran / 1 h / -78 - 20 °C

4.1: sodium azide / dimethyl sulfoxide / 2 h / 20 °C

4.2: 48 h / 20 °C

With lithium borohydride; sodium azide; ethanol; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;