85963-90-2

Basic information

• Product Name: methyl 2-(4-bromobenzoyl)-3-oxo-butanoate
• Synonyms: methyl 2-(4-bromobenzoyl)-3-oxo-butanoate
• CAS NO: 85963-90-2
• Molecular Weight: 299.121
• Mol File: 85963-90-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-bromobenzoyl)-3-oxo-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-bromobenzoyl)-3-oxo-butanoate(85963-90-2)
• EPA Substance Registry System: methyl 2-(4-bromobenzoyl)-3-oxo-butanoate(85963-90-2)

Safety Data

• Hazardous Substances Data: 85963-90-2(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 586-75-4 4-chlorobenzoyl chloride 
• 13412-12-9 3-methylaminobut-2-enoic acid methyl ester 

Downstream Products

• 1228689-61-9 methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate 
• 91182-60-4 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid 
• 1280205-98-2 (5-(4-bromophenyl)-3-methylisoxazole-4-yl)methanol 
• 1267684-96-7 5-(4-bromophenyl)-3-methylisoxazole-4-carbaldehyde 
• 1280206-27-0 1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 
• 1280206-29-2 1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 
• 1280206-15-6 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole 
• 1280206-16-7 [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetonitrile 
• 1280206-14-5 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid 
• 1280206-18-9 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid ethyl ester 
• 1280732-36-6 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide 
• 1280732-37-7 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-5-phenyl-[1,3,4]oxadiazole 
• 1280732-55-9 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid hydrazide 
• 1280206-91-8 1-[4'-(4-Formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 

Relevant articles and documents

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.