85963-90-2

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 13412-12-9 3-methylaminobut-2-enoic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1228689-61-9 methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate 
• 91182-60-4 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid 
• 1280205-98-2 (5-(4-bromophenyl)-3-methylisoxazole-4-yl)methanol 
• 1267684-96-7 5-(4-bromophenyl)-3-methylisoxazole-4-carbaldehyde 
• 1280206-27-0 1-[4'-(4-hydroxymethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 
• 1280206-29-2 1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 
• 1280206-15-6 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole 
• 1280206-16-7 [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetonitrile 
• 1280206-14-5 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid 
• 1280206-18-9 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid ethyl ester 
• 1280732-36-6 [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide 
• 1280732-37-7 2-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-5-phenyl-[1,3,4]oxadiazole 
• 1280732-55-9 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid hydrazide 
• 1280206-91-8 1-[4'-(4-Formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in com

POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Compounds as Lysophosphatidic Acid Receptor Antagonists

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in com

ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.