1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate
CAS No.:1262108-32-6
Molecular Formula:C₂₄H₂₅ClFN₃O₇
Molecular Weight:521.93
Hs Code.:

Synonyms:1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

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Chemical Property of 1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

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Technology Process of 1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

There total 4 articles about 1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262108-07-5
4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl chloride

: 129799-08-2
tert-butyl methyl piperazine-1,3-dicarboxylate

: 1262108-32-6
1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield:

: 160591-91-3
4-chloro-2-fluorophenylboronic acid

: 1262108-32-6
1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 14 h / 90 °C / Inert atmosphere

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 14 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

With oxalyl dichloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 6950-43-2
5-bromo-2-nitrobenzoic acid

: 1262108-32-6
1-tert-butyl 3-methyl 4-(4'-chloro-2'-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 14 h / 90 °C / Inert atmosphere

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 14 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

With oxalyl dichloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;