160591-91-3

Basic information

• Product Name: 4-Chloro-2-fluorophenylboronic acid
• Synonyms: AKOS BRN-0717;4-CHLORO-2-FLUOROPHENYLBORONIC ACID;4-CHLORO-2-FLUOROBENZENEBORONIC ACID;4-Chloro-2-fluorobenzeneboronic acid 98%;4-Chloro-2-fluorobenzeneboronicacid98%;4-chloro-2-fluorobenzenboronic acid;Boronic acid, B-(4-chloro-2-fluorophenyl)-;1-Borono-4-chloro-2-fluorobenzene
• CAS NO: 160591-91-3
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• Product Categories: blocks;BoronicAcids;Aryl;Organoborons
• Mol File: 160591-91-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 248-250
• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.19±0.58(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 4-Chloro-2-fluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-fluorophenylboronic acid(160591-91-3)
• EPA Substance Registry System: 4-Chloro-2-fluorophenylboronic acid(160591-91-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 160591-91-3(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Different sources of media describe the Uses of 160591-91-3 differently. You can refer to the following data:
1. Used as intermediates for pharmaceutical and agrochemicals.
2. suzuki reaction

InChI:InChI=1/C6H5BClFO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H

Upstream product

• 121-43-7 Trimethyl borate 
• 6797-79-1 4-chloro-2-fluoro-1-iodobenzene 
• 1996-29-8 1-bromo-4-chloro-2-fluorobenzene 
• 7732-18-5 water 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 313668-24-5 tert-butyl (6AS,10AR)-2-(4-chloro-2-fluorophenyl)-4,5,7,8, 10,10a-hexahydropyrido[4,3-b]pyrrolo[3,2,1-hi]indole-9(6AH)-carboxylate 
• 1108185-00-7 C₂₄H₂₂ClFN₄O 
• 1265398-90-0 methyl 2-(4-(4-chloro-2-fluorophenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate 
• 1265401-77-1 methyl 2-(4-(4-chloro-2-fluorophenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate 
• 50558-21-9 2-chlorobiphenylene 
• 39224-18-5 4-chloro-2-fluoro-1,1'-biphenyl 
• 1398519-69-1 C₂₂H₁₆ClFN₂O₃ 
• 1398503-20-2 (2R)-4-[4-(4-chloro-2-fluorophenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)butanoic acid 
• 1398503-21-3 (2R)-4-[4-(4-chloro-2-fluorophenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1398501-80-8 (2R)-4-[4-(4-Chloro-2-fluorophenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide 
• 1262107-90-3 7-(4-chloro-2-fluorophenyl)-2-(3,3-dimethylbutyl)-1,3,4,11a-tetrahydro-2H,10H-2,4a,10-triazadibenzo[a,d]cycloheptene-5,11-dione 
• 1262108-11-1 7-(4-chloro-2-fluorophenyl)-1,3,4,11a-tetrahydro-2H,10H-2.4a,10-triazadibenzo[a,d]cycloheptene-5,1-dione 
• 1262107-40-3 7-(4-chloro-2-fluorophenyl)-2-(3,3-dimethylbutyryl)-1,3,4,11a-tetrahydro-2H,10H-2,4a,10-triazadibenzo[a,d]cycloheptene-5,11-dione 
• 1262108-09-7 1-tert-butyl 3-methyl 4-(4-amino-4'-chloro-2'-fluoro-biphenyl-3-carbonyl)piperazine-1,3-dicarboxylate 

Relevant articles and documents

Synthesis of Biphenylenes and Their Higher Homologues by Cyclization of Aryne Derivatives

This investigation demonstrates that a series of biphenylenes can be easily prepared from their corresponding halobiphenyls by the cyclization of in situ generated 2′,3′-didehydro-2-lithiobiphenyls at low temperature. Two remarkable advantages of this synthetic method include 1) the lack of any need for transition-metal catalysts or reagents in the cyclization, and 2) the ability to obtain C1-functionalized products by treating the reaction intermediate 1-lithiobiphenylene with an electrophilic reagent. π-Extended derivatives, such as benzobiphenylenes, dibenzobiphenylene, linear/angular [3]phenylenes, and biphenyleno[2,3-b]biphenylenes, were synthesized similarly using suitable biaryls or teraryls.

BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as "BPSAAA compounds"), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.