tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1241959-29-4
Molecular Formula:C₃₄H₄₃NO₄Si
Molecular Weight:557.805
Hs Code.:

Synonyms:tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

There total 5 articles about tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1241959-28-3
tert-butyl (S)-1-(benzyloxy)but-3-en-2-yl((R,E)-2-(tert-butyldiphenylsilyloxy)pent-3-enyl)carbamate

: 1241959-29-4
tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; for 48h; Inert atmosphere; Reflux;
DOI:10.1021/ol101556k

Reference yield:

: 1241959-25-0
(R,E)-N-((S)-1-(benzyloxy)but-3-en-2-yl)-2-(tert-butyldiphenylsilyloxy)pent-3-en-1-amine

: 1241959-29-4
tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 h / 50 °C / Inert atmosphere

2: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux; Inert atmosphere

With Grubbs catalyst first generation; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201200377

Reference yield:

: C₂₁H₂₆O₂Si

: 1241959-29-4
tert-butyl (3R,6S)-6-((benzyloxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / 20 h / 20 °C / Inert atmosphere

1.2: -90 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 20 h / 50 °C / Inert atmosphere

3.1: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux; Inert atmosphere

With Grubbs catalyst first generation; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201200377